Type I and type III interferon in opposition?
نویسندگان
چکیده
منابع مشابه
Antiviral Type I and Type III Interferon Responses in the Central Nervous System
The central nervous system (CNS) harbors highly differentiated cells, such as neurons that are essential to coordinate the functions of complex organisms. This organ is partly protected by the blood-brain barrier (BBB) from toxic substances and pathogens carried in the bloodstream. Yet, neurotropic viruses can reach the CNS either by crossing the BBB after viremia, or by exploiting motile infec...
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چکیده ندارد.
Interfering with type I Interferon
Scientists have been investigating the critical role type 1 interferons (IFN-I) play in controlling viral infections for more than 50 y. Common pathogen motifs present on viral particles trigger intracellular and membrane-associated pattern recognition receptors, leading to the production of IFN-I and rapid expression of interferon stimulated genes (ISIGs). ISIGs encode proteins with direct ant...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2020
ISSN: 1474-1733,1474-1741
DOI: 10.1038/s41577-020-0340-3